منابع مشابه
Modeling of Ion Channels
Modeling of biological ion channels has a long history, going back more then 100 yr (Hille 1984). In the old, premolecular biology era, interpretation of these simple models provided the primary source of information about channel structure. As molecular biology and, now, x-ray diffraction have provided direct information about structure, modeling has been reduced to playing more of a secondary...
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The recent determination of several crystal structures of voltage-gated ion channels has catalyzed computational efforts of studying these remarkable molecular machines that are able to conduct ions across biological membranes at extremely high rates without compromising the ion selectivity. Starting from the open crystal structures, we have studied the gating mechanism of these channels by mol...
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Recent studies show that an array of beta-sheet peptides, including N-terminally truncated Abeta peptides (Abeta(11-42/17-42)), K3 (a beta(2)-microglobulin fragment), and protegrin-1 (PG-1) peptides form ion channel-like structures and elicit single channel ion conductance when reconstituted in lipid bilayers and induce cell damage through cell calcium overload. Striking similarities are observ...
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Over the past decade, a number of groups have reported that oligomeric intermediates populated during the conversion of proteins from a monomeric disaggregated state into amyloid fi brils can permeabilize lipid bilayers and cell membranes. Some of these studies have presented electrical current traces that suggest the formation of discrete oligomeric membrane ion channels, which exhibit selecti...
متن کاملModeling and simulation of ion channels.
Ion channels are formed by specific proteins embedded in the cell membrane and provide pathways for fast and controlled flow of selected ions through the channels. Ion channels generate action potentials in nerves, muscles and other excitable cells, and are the basis of all movement, sensation and thought processes in living beings. While the functional properties of ion channels are well known...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2009
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2008.12.389